Problem: I cannot run any setup.exe files. I'm getting a message that my computer does not know what program to use to run Setup.exe?

This condition sounds like the haxdoor virus

Download haxfix.exe
and select the "Run" option.
A red "dos window" (dos box) will open with options:
1. Make logfile
2. Run auto fix
3. Run manual fix
E. Exit Haxfix

Select option 2. Run auto fix by typing 2 and then pressing Enter

Haxfix will start scanning the computer.

The exe file is actually a self extracting zip file so it might work, if not right click it and select extract to, then follow rest of instructions